TriSalus Life Sciences Announces Oral Presentations at the Upcoming 2024 Society of Interventional Radiology (SIR) Annual Scientific Meeting
TriSalus will share data on the technical feasibility and safety of Pressure-Enabled Drug Delivery™ (PEDD) procedures in hypovascular tumors and initial data regarding our Pancreatic infusion technology, which is currently 510(k) cleared by the
The TriSalus approach seeks to address many of the key challenges associated with delivering therapeutics to pancreas tumors. In contrast to the liver, pancreas arteries feeding tumors are difficult to access and venous access affords anatomic advantages. Additionally, pancreatic tumors exhibit a dense, desmoplastic stroma that limits the delivery of therapeutics. The technology is designed to address these mechanical barriers and challenges by modulating pressure and flow, incorporating real-time pressure sensing capability to optimize safety and delivery.
“The presentations featuring our PEDD approach illustrates that TriSalus is committed to and focused on transforming how therapeutics are delivered into biologically challenging liver and pancreas tumors. Mechanical barriers present in the tumor microenvironment, including high intra-tumoral pressure, may limit the performance of many therapeutic classes including embolics and immunotherapy. We look forward to our continued partnership with the interventional radiology community to improve outcomes in a variety of solid tumor indications,” noted
Presentation details for SIR 2024 are as follows:
Presentation: Clinical Efficacy of Pressure-Enabled Transarterial Embolization of Hypovascular, Treatment-Refractory Metastases.
Presenting Author: Koustav Pal, MBBS, Postdoctoral Research Fellow at
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Presentation: The PERIO-03 Trial: Technical Feasibility and Safety of a Novel Pancreatic Retrograde Venous Immunotherapy Infusion Intervention for Locally Advanced Pancreatic Ductal Adenocarcinoma.
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The presentations will be available on the publications page of the TriSalus website following the respective sessions.
About TriSalus Life Sciences
TriSalus Life Sciences is an oncology company integrating novel delivery technology with immunotherapy to transform treatment for patients with liver and pancreatic tumors.
The Company’s platform includes devices that utilize a proprietary drug delivery technology and a clinical-stage investigational immunotherapy. The Company’s two FDA-cleared devices that deliver a range of therapeutics, using its proprietary Pressure-Enabled Drug Delivery™ (PEDD™) approach: the TriNav® Infusion System for hepatic arterial infusion of liver tumors and the Pancreatic Retrograde Venous Infusion System for pancreatic tumors. PEDD is a novel delivery approach designed to address the anatomic limitations of arterial infusion to the pancreas. The PEDD approach modulates pressure and flow in a manner that delivers more therapeutic to the tumor and is designed to reduce undesired delivery to normal tissue, bringing the potential to improve patient outcomes. Nelitolimod (SD-101), the Company’s investigational immunotherapeutic candidate, is designed to improve patient outcomes by treating the immunosuppressive environment created by many tumors, which can make current immunotherapies ineffective in the liver and pancreas. Patient data generated during Pressure-Enabled Regional Immuno-Oncology™ (PERIO) clinical trials support the hypothesis that SD-101 delivered via PEDD may have favorable immune effects within the liver and systemically. The target for SD-101, TLR9, is expressed across cancer types and the mechanical barriers addressed by PEDD are commonly present as well. Nelitolimod delivered by PEDD will be studied across several indications in an effort to address immune dysfunction and overcome drug delivery barriers in the liver and pancreas.
In partnership with leading cancer centers across the country – and by leveraging deep immuno-oncology expertise and inventive technology development – TriSalus is committed to advancing innovation that improves outcomes for patients. Learn more at trisaluslifesci.com and follow us on X (formerly Twitter) and LinkedIn.
Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical facts contained in this report, including statements regarding the Company’s expected financial results for the three months ended
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Source: TriSalus Life Sciences