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  <xs:element id="tlsi_ReverseRecapitalizationTransactionCostsIncurred" abstract="false" name="ReverseRecapitalizationTransactionCostsIncurred" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_LoanFacilityMember" abstract="true" name="LoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PreferredStockWarrantMember" abstract="true" name="PreferredStockWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ReverseRecapitalizationLineItems" abstract="true" name="ReverseRecapitalizationLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_SaleOfStockAuthorizedAmountValue" abstract="false" name="SaleOfStockAuthorizedAmountValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_SharePriceAsPercentageOfMarketPriceCommencingOnAdvanceNoticeDate" abstract="false" name="SharePriceAsPercentageOfMarketPriceCommencingOnAdvanceNoticeDate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_DerivativeFinancialInstrumentsWarrantLiabilityMember" abstract="true" name="DerivativeFinancialInstrumentsWarrantLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_StockConvertedReverseRecapitalization" abstract="false" name="StockConvertedReverseRecapitalization" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightConversionTermsThresholdTradingDays" abstract="false" name="ClassOfWarrantOrRightConversionTermsThresholdTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightThresholdNumberOfDaysForWarrantsToBeTransferable" abstract="false" name="ClassOfWarrantOrRightThresholdNumberOfDaysForWarrantsToBeTransferable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_MeasurementInputExpectedProbablyOfDrawsMember" abstract="true" name="MeasurementInputExpectedProbablyOfDrawsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_PaymentsForAssetAcquisitionMilestoneAmount" abstract="false" name="PaymentsForAssetAcquisitionMilestoneAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_NatureOfBusinessLineItems" abstract="true" name="NatureOfBusinessLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tlsi_NumberOfProductLinesInDevelopment" abstract="false" name="NumberOfProductLinesInDevelopment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_NumberOfEquityIncentivePlans" abstract="false" name="NumberOfEquityIncentivePlans" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tlsi_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesOutstanding" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesOutstanding" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentPeriodOneMember" abstract="true" name="DerivativeInstrumentPeriodOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_StandbyEquityPurchaseAgreementMember" abstract="true" name="StandbyEquityPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightRedemptionPrice" abstract="false" name="ClassOfWarrantOrRightRedemptionPrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tlsi_ClassOfWarrantsOrRightsIssuedInThePeriod" abstract="false" name="ClassOfWarrantsOrRightsIssuedInThePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tlsi_ClassOfWarrantOrRightTerm" abstract="false" name="ClassOfWarrantOrRightTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodVestingPercentage" abstract="false" name="DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriodVestingPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="tlsi_DerivativeFinancialInstrumentsSeriesB3WarrantLiabilityMember" abstract="true" name="DerivativeFinancialInstrumentsSeriesB3WarrantLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_ProceedsFromReverseRecapitalizationTransaction" abstract="false" name="ProceedsFromReverseRecapitalizationTransaction" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentPeriodDomain" abstract="true" name="DerivativeInstrumentPeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentPeriodFourMember" abstract="true" name="DerivativeInstrumentPeriodFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tlsi_DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriod" abstract="false" name="DerivativeInstrumentContingentConsiderationLiabilityEarnoutPeriod" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
</xs:schema>
